Pizzeria Uno is a Pizza restaurant in Chicago (River North), $$; open Mon–Sun 11:00–23:00.
The original Chicago deep-dish stop, serving hearty pizza in a cozy River North landmark. Pizzeria Uno is the original home of Chicago deep-dish pizza, opened by Ike Sewell in 1943. Its hearty pies layer flavorful toppings into a distinctive, perfectly baked crust, with the deep dish taking time in the oven. The historic River North setting feels cozy and unmistakably Chicago, while friendly service and family-friendly dining make it a popular stop for groups and visitors.